The dosage recommendations for Resveratrol depend on the ailment for which it is targeted. Every ailment has its own respective dosages. The supplements of Resveratrol are available in dosages which are pre-formulated and in different combinations with many other ingredients. Trans-Resveratrol is the active form of Resveratrol. This is more stable chemically and comes with lot of benefits. But Cis-Resveratrol which is the inactive form of this Resveratrol is less beneficial. So, Cis-Resveratrol is in use in topical creams and it is found in most of the oral supplements of Resveratrol.
Best dosage recommended:
It is very effective in giving protection against negative effects caused by obesity. This is due to its anti-oxidant properties. Some of the negative effects of obesity where in Resveratrol is effective include high blood pressure, diabetes, hardening of arteries, and LDL bad cholesterol.
It can act as anti-inflammatory in some of the chronic inflammations like deafness due to aging. It can increase blood flow in brain which results in many benefits. It is also effective in Alzheimer’s.
Resveratrol even has anti-cancer properties. Experts always recommend Mediterranean diet because they consume good amount of Resveratrol dosage for oral consumption through wine that is 0.2mg daily. Red wine is the best source for resveratrol. Other sources which supply resveratrol include red grape skins, berries, pomegranate and nuts. In deriving supplements, usually they use Knotweed polypodium Cuspidatum from Japan as a source for resveratrol. This is because of one more reason that year round it can be harvested.
Some of the sources of resveratrol can contain a compound called emodin. Which is not good for health. It can cause stomach discomfort and even diarrhea in some cases.
Resveratrol is always recommended to take in the morning time. Since there will be circadian rhythm caused by this supplement it is not good to take this in the evening. Dosage also depends on the individuals and their health conditions. At lower doses this is not very pronounced.
But if one increases the dose then there will be doubling of effects. Mega doses are not recommended. Whichever may be the ailment it is recommended to start with lower dose and then increase it gradually based on the effects it is causing on the body chemistry. 1-3 hours is range for half-life of the resveratrol which can be increased to 2-5 hours by the usage of multiple doses.
Longevity and resveratrol:
When it comes controlling the blood pressure, supplement is recommended in low doses because it is very effective. One of the studies which have conducted on mice stated that resveratrol was very effective in the treatment of allergic disease in airways. They used 12.5mg/kg of the supplement. It is also effective in treating tissue inflammation.
Dosages between 150mg-445mg is recommended for the purposes like cardiovascular health, longevity, insulin sensitivity. In obese individuals when they used 150mg daily it has shown significant improvement in insulin sensitivity within 30days.
It is effective in glucose metabolism. Lower doses should be used in people with diabetic conditions. In case of people with pre-clinical disease states, higher doses must be used.